Publications
2026
H Zhang#, Z Zhang#, P Wang#, T Xu, X Chen, Y Zhao, S Lin, W Cai, P Ren, C Luo, P Zhang, Y Wang, S Hou, Y Zhao, H Zeng*, Z Liu, C Wang, Z Gao, Y Feng*, D Pan*, Z Zeng*. Uncovering spatially resolved functional genomics with CRISPR screen sequencing. Cell (2026), online ahead of print. DOI: 10.1016/j.cell.2026.04.049. get the PDF
C Luo#, C Cheng#, X Zhao#, J Zhou#, Z Jing, Q Ma, L Ye, K Zhu, L Zhao, H Xu, H Zeng*. Targeting cancer-associated cell surface RNAs with oligonucleotide-drug conjugates enables broad antitumor activity. bioRxiv (2026), 2026.05.08.723688. get the PDF
J Ren#, H Zeng#, J Huang#, J Tian, M Wu, H Shi, X Sui, C K Wang, H Zhou, Z Tang, S Luo, X Wang*. Spatially resolved in situ profiling of mRNA life cycle at transcriptome scale in intact cells and tissues using STARmap PLUS, RIBOmap and TEMPOmap. Nat. Protoc. (2026) 21, 1629–1661. get the PDF
2025
T Hui#, J Zhou#, M Yao, Y Xie, H Zeng*. Advances in spatial omics technologies. Small Methods (2025), e2401171. (Review)get the PDF
D Bai#, J Yang#, X Xue#, Y Gao#, Y Wang, M Cui, B He, H Zeng, H Xiang, Z Guo, L Zhu, J Gao, C Zhu*, F Tang*, C Yi*. Single-cell 5-hydroxymethylcytosine landscapes of mouse early embryos at single-base resolution. Cell Rep. (2025) 44, 115520. get the PDF
2024
Z Tang#, S Luo#, H Zeng, J Huang, X Sui, M Wu, X Wang*. Search and match across spatial omics samples at single-cell resolution. Nat. Methods (2024) 21, 1818–1829. get the PDF
2023
H Zeng#, J Huang#, J Ren#, C K Wang, Z Tang, H Zhou, Y Zhou, H Shi, A Aditham, X Sui, H Chen, J A Lo, X Wang*. Spatially Resolved single-cell translatomics at molecular resolution. Science (2023) 380, eadd3067. (Highlighted in the Nature Reviews Genetics and Nature Methods ).get the PDF
J Ren#, H Zhou#, H Zeng#, C K Wang, J Huang, X Qiu, X Sui, Q Li, X Wu, Z Lin, J A Lo, K Maher, Y He, X Tang, J Lam, H Chen, B Li, D E Fisher, J Liu, X Wang*. Spatiotemporally resolved transcriptomics reveals the subcellular RNA kinetic landscape. Nat. Methods (2023) 20, 695–705. get the PDF
H Zeng#, J Huang#, H Zhou#, W J. Meilandt, B Dejanovic, Y Zhou, C J. Bohlen, S Lee, J Ren, A Liu, Z Tang, H Sheng, J Liu, M Sheng *, X Wang*. Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer’s disease. Nat. Neurosci. (2023) 26, 430–446.get the PDF
Before 2023
B He#, C Zhang#, X Zhang#, Y Fan#, H Zeng, J Liu, H Meng, D Bai, J Peng, Q Zhang*, W Tao*, C Yi*. Tissue-specific 5-hydroxymethylcytosine landscape of the human genome. Nat. Commun. (2021) 12:4249.get the PDF
M Liu#, J Zhang#, C Zhu#, X Zhang, W Xiao, Y Yan, L Liu, H Zeng, YQ Gao*, C Yi*. DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes. Nat. Commun. (2021) 12:4108.get the PDF
A Aditham#, H Shi#, J Guo, H Zeng, Y Zhou, S D Wade, J Huang, J Liu, X Wang*. Chemically modified mocRNAs for highly efficient protein expression in mammalian cells. ACS Chem. Biol. (2022) 17, 3352-3366.get the PDF
H Zeng#, M Mondal#, R Song#, J Zhang, B Xia, M Liu, C Zhu, B He, YQ Gao* and C Yi*. Unnatural cytosine bases recognized as thymines by DNA polymerases via the formation of the Watson-Crick geometry. Angew. Chem. Int. Ed. (2019) 58, 130-133.get the PDF
H Zeng#, B He#, C Yi*. Compilation of modern technologies to map genome-wide cytosine modifications in DNA. Chembiochem (2019) 20, 1898-1905.(Review)get the PDF
H Zeng#, B He#, B Xia, D Bai, X Lu, J Cai, L Chen, A Zhou, C Zhu, H Meng, Y Gao, H Guo, C He*, Q Dai*, and C Yi*. Bisulfite-Free, Nanoscale Analysis of 5-Hydroxymethylcytosine at Single Base Resolution. J. Am. Chem. Soc. (2018) 140, 13190-13194.get the PDF
H Zeng#, B He#, C Yi*, and J Peng*. Liquid biopsies: DNA methylation analyses in circulating cell-free DNA. J. Genet. Genomics (2018) 45, 185-192. (Review)get the PDF
C Zhu#, Y Gao#, H Guo#, B Xia#, J Song, X Wu, H Zeng, K Kee, F Tang*, and C Yi*. Single-Cell 5-Formylcytosine Landscapes of Mammalian Early Embryos and ESCs at Single-Base Resolution. Cell Stem Cell (2017) 20, 720-731 e725.get the PDF
B Xia#, D Han#, X Lu#, Z Sun, A Zhou, Q Yin, H Zeng, M Liu, X Jiang, W Xie, C He*, and C Yi*. Bisulfite-free, base-resolution analysis of 5-formylcytosine at the genome scale. Nat. Methods (2015) 12, 1047-1050.get the PDF